Acitretin API

Khoom npe: Acitretin
CAS Naj Npawb: 55079-83-9
MOQ: 1 kg
Kev Ntsuas: 99%
Brand: YIHUI
Ntim: 1kg / hnab; 5kg / hnab
Muaj peev xwm muab khoom: 300kg ib hlis
Siv: qib tshuaj; los yog tshawb fawb
Lub sij hawm xa tuaj: hauv Tshuag
Txee Lub neej: Ob xyoos
Kev Them Nyiaj: T / T, LC lossis DA
Muag tsis tau rau tib neeg
Xa Nug
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khoom Introduction

Acitretin API yog dab tsi?

Acitretin API, yog ib qho tshuaj ua los ntawm vitamin A, tseem hu ua all-trans retinoic acid los yog betarretin A. Nws tswj ntau npaum li cas ntawm daim tawv nqaij proliferate thiab sib txawv thaum tseem cuam tshuam li cas lub stratum corneum tsim. Nws txhim kho cov kab mob xws li keratosis, txo pob txuv, thiab tswj cov tawv nqaij pigmentation los ntawm kev txuas mus rau vitamin A acid receptor nyob rau hauv lub nucleus ntawm cov hlwb thiab hloov cov noob transcription thiab protein qhia. Nrog rau qhov hnyav molecular ntawm 326.43 g / mol thiab cov tshuaj formula C21H26O3, nws feem ntau siv cov xim daj los yog crystalline hmoov. Nws muaj tus lej CAS 55079-83-9. Hexane tuaj yeem siv los ua kom ruaj khov, thiab nws cov ntsiab lus melting yog 228 - 230 ° C. LD50 los ntawm kev txhaj tshuaj intraperitoneal yog li ntawm> 4000 mg / kg (1 hnub) txog 700 mg / kg (10 hnub thiab 20 hnub), raws li kev tshawb nrhiav ntawm cov tshuaj lom neeg mob hnyav hauv cov nas. Lub active metabolite ntawm tretinoin yog acitretin, ib tug synthetic qab zib counterpart ntawm vitamin A. Ntxiv nrog rau lwm yam tawv nqaij mob, nws yog siv los kho mob hnyav psoriasis thiab keratosis.

Cov lus 

Khoom npe: Acitretin

CAS: 55079-83-9

MF: C21H26O3

MW: 326.43

EINECS: 259-474-4

MDL No.: MFCD00866632

Melting point: 228-230 ° C

Kub taw tes: 404.46 ° C (kwv yees ntxhib)

Density 1.1348 (kwv yees ntxhib)

Refractive Index 1.4700 (kwv yees)

cia temp. -20 ° C

Stability: ruaj khov

Tus qauv qauv:

55079-83-9.webp ib

Cov qauv zoo 

Cov khoom

Specifications

tau

tsos

Daj los yog ntsuab-daj-dawb crystalline hmoov

daj crystalline hmoov

Identification

Ntsuas cov cai

Ntsuas cov cai

solubility

Xyaum insoluble hauv dej, sparingly soluble hauv tetrahydrofuran, me ntsis soluble hauv acetone thiab cawv, me ntsis soluble hauv cyclohexane

Cov Qauv

Residual kuab tshuaj

(raws li Ethyl Acetate)

≤0.01%

Cov Qauv

Poob rau kom qhuav

≤0.5%

0.3%

Sulfated tshauv

≤0.1%

0.05%

Cov hlau hnyav

≤0.002%

palladium

≤0.001%

Tsis kuaj

particle loj

Tapped ntom

Loose ntom

100% ≤ 60um

Cov Qauv

0.386g / ml

0.205g / ml

lwm yam tshuaj

Tus kheej impurity: ≤0.3%

0.26%

Tag nrho cov impuritites: ≤1.0%

0.35%

Assay (Nyob rau hauv qhuav)

98.0% -102.0%

99.4%

Xaus: Nws ua raws li EP

Packing cia: nyob rau hauv nruj ntim. Cov hmoov qhuav ntawm chav tsev kub tswj.

Function & Application

Acitretin API yog ib qho tshuaj noj hauv qhov ncauj uas nyob rau hauv chav kawm retinoid ntawm cov tshuaj. Nws yog feem ntau siv los kho ntau yam tawv nqaij mob, tshwj xeeb tshaj yog mob psoriasis (mob plaque psoriasis), keratinization mob, thiab palmoplantar keratoderma.

Hauv qab no yog cov npe ntawm nws daim ntawv thov thiab kev ua haujlwm:

  • Psoriasis kev kho mob: nws txo qhov khaus, scaling, liab me ntsis, thiab ob leeg mob txuam nrog psoriasis. Nws tswj cov cellular faib thiab kev loj hlob, uas txo cov keratinization ntau dhau thiab cov tshuaj tiv thaiv inflammatory thiab txo qhov hnyav ntawm psoriasis.

  • Kev kho cov kab mob keratinization: nws tuaj yeem siv los kho loricrin keratoderma thiab non-epidermolytic palmoplantar keratoderma. Cov tsos mob thiab saib ntawm daim tawv nqaij yog txhim kho los ntawm kev txo cov tawv nqaij keratinization ntau dhau.

  • Kev kho mob ntawm palmoplantar keratoderma: nws tuaj yeem kho palmoplantar keratoderma los ntawm kev txo cov tuab thiab qib ntawm keratinization hauv xib teg thiab ob txhais taw, txo cov tsos mob xws li mob, tawg, thiab nce keratinization.

Nws tuaj yeem ua rau muaj kev phiv thaum kho, xws li lub qhov ncauj qhuav, cheilitis, qhov muag tsos mob, thiab hloov siab ua haujlwm, yog li nws tseem ceeb heev kom paub txog qhov no. Yog li ntawd, nws yuav tsum tau siv nyob rau hauv kev saib xyuas ntawm tus kws kho mob, nrog rau kev ntsuam xyuas tsis tu ncua ntawm nws cov kev ua tau zoo thiab kev nyab xeeb. Nws tseem tsis tau qhia rau kev siv los ntawm cov poj niam uas tab tom tos lossis laus vim tias nws tuaj yeem ua mob rau tus menyuam hauv plab lossis cov menyuam mos.

Cov kev phiv tshuaj

Daim di ncauj qhuav, cheilitis, angular stomatitis, qhuav los yog khaus qhov ncauj mucosa, thiab transitional epithelium yog cov cim qhia ntawm cov vitamin A siab. Intolerance rau qhov muag lo ntsiab muag, keratitis, corneal ulceration, thiab conjunctivitis. cov tsos mob ntawm plab hnyuv o. nqhis dej thiab hws. plaub hau poob uas thim rov qab. daim tawv nqaij uas yog thinner thiab scaly. Paronychia, qhov txawv ntawm tus ntsia thawv loj hlob, granuloma, thiab qee zaum pob txha, pob qij txha, thiab mob leeg. txo qis lipoprotein ceev, nce triglycerides thiab roj cholesterol, nce transaminases thiab alkaline phosphatase. Cov tsos mob ntawm intracranial siab muaj xws li mob taub hau, qhov muag tsis pom kev, ntau calcification, extraosseous calcification, osteoporosis, thiab thaum ntxov epiphyseal phaj kaw.

Txheej txheem ntau lawm

4-methoxy-2,3,6-trimethylbenzaldehyde (Ⅰ) thiab ethyl formate react nyob rau hauv phosphoric acid-muaj ethanol kom yield compound (Ⅱ) nrog ib tug yield ntawm 84%. Tom qab ntawd, nws hnov ​​​​mob nrog (Ⅲ) hauv ethyl acetate uas muaj zinc chloride kom tawm los sib xyaw ntawm 6: 4 (E) - (Ⅳ) thiab (Z) - (Ⅳ), nrog rau tag nrho cov txiaj ntsig ntawm 83%. Kev tshem tawm cov kua qaub muab 27% ntawm (E, E)-(V) thiab 21% ntawm (Z, E)-(V). (E, E)-(V) reacts nrog acetone nyob rau hauv ib tug methanol-dej tov kom yield 25% ntawm compound (Ⅵ). Nws reacts nrog ethoxyethynylmagnesium bromide Grignard reagent nyob rau hauv ether kom yield compound (Ⅶ) nrog ib tug yield ntawm 48%. Thaum kawg, hydrolysis yields 91% cov khoom.

Stability & cia

Nws yog ib qho derivative ntawm vitamin A acid. Nws stability thiab cia tej yam kev mob yog raws li nram no:

Stability: Nws tuaj yeem ruaj khov rau lub sijhawm ntev thaum khaws cia rau hauv qhuav, tiv thaiv lub teeb, thiab kaw qhov xwm txheej. Txawm li cas los xij, nws yog rhiab heev rau lub teeb thiab tuaj yeem yooj yim degrade thiab poob zoo thaum raug teeb. Tsis tas li ntawd, Nws tseem muaj kev nkag siab rau qhov kub thiab txias thiab oxygen, uas yuav txo tau nws txoj kev ruaj ntseg.

Cia tej yam kev mob: Yuav kom ruaj ntseg ntawm nws, cov nram qab no cia tej yam kev mob raug pom zoo:

  • Kub: Khaws rau hauv chav sov (15 ° C - 30 ° C).

  • Humidity: Khaws cov av noo tsawg thiab tsis txhob muaj qhov chaw ntub dej.

  • Lub teeb: Muab tso rau hauv cov thawv uas tiv thaiv lub teeb kom tsis txhob raug lub teeb ncaj qha.

  • Ntim: Siv cov thawv ntim khoom ntim lossis cov khoom ntim los xyuas kom muaj kev sib khi zoo.


Ntim & Xa Khoom

Cov: 1kg / foil hnab; 5kg / carton; 25kg / fiber nruas; los yog ntim raws li koj qhov kev thov.

customization:Customized logo; Customized ntim; Graphic customization

Shipping:

Yam

kom muaj nuj nqis

Lub sijhawm ETA

Cov Txheej Txheem Xa Khoom

Los ntawm Courier

50kg

7-15days

Fedex, DHL, UPS, TNT, EMS thiab lwm yam.

Ceev thiab yooj yim

Los Ntawm Cua

50kg ~ 200kg

3-5days

Ceev thiab pheej yig

Ntawm Hiav Txwv

Ntau qhov ntau

20-35days

Txoj kev pheej yig tshaj

Payment Term

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Muab cov khoom sib txawv: cov khoom siv tau siv rau txhua lub npe loj thoob ntiaj teb hauv kev siv tshuaj, tshuaj noj, tshuaj pleev ib ce, tsiaj noj zaub mov thiab khoom noj khoom haus.

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Nyob rau hauv xaus

Hauv kev xaus, raws li tus kws tshaj lij Acitretin API chaw tsim tshuaj paus, peb muaj advanced technology, scale kom zoo dua, qhov zoo tshaj plaws zoo, nplua nuj ntau lawm kev, thiab cov kev pab zoo heev. Cov txiaj ntsig zoo no yuav ua rau nws sawv hauv kev sib tw ua lag luam thiab yeej ntau tus neeg siv khoom ntseeg siab thiab kev txhawb nqa. Yog tias koj xav tau, pls xav tiv tauj peb txhua lub sijhawm. peb yuav teb koj asap.

peb cov ntaub ntawv tiv tauj:

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